This works with ALL areas, but only some spots are documented. So if you find a common pattern somewhere be sure to let us know in the forums and we'll add it here.
Heres some quick guides to get some of the common quests and runs without needing to resort to using maphack.
Nilithak
Once you nab the waypoint there are only three possible paths that you can take to get to the next level. Here they are:
Path of Diablo is an international server that allows all our players from around the world to trade, play and compete together but without high latency. This is achieved by keeping all players on one single realm and ladder, while also allowing them to create their games on one of our 28+ servers around the world. BECOME A PATRON: Tip Jar: Me on Facebook. To execute correct map layouts, you must understand your character's orienation to the map. Look at your character's. Point of view of what's straight, left, or right. It is never north, east, west, south. The correct direction will be based on. (1) if it exists, the map layout - (2) the direction your character is facing whenever.
Maphack With Path Of Diablo
The action that actually triggers the portal to leave is nabbing the waypoint. However, I still say nab the waypoint. Why? Because without the waypoint, you will have far too long of a trip for these runs to be efficient...
To speed up finding Nihlathak in the final area, he will be in room opposite the room with the champions in the back. With this being said maximum rooms u will check are 3 and not four now.
Path Of Diablo Maphack
Countess
There are 4 patterns
If you come out of the door and you can only move:
UP RIGHT, next level is UP LEFT
UP LEFT, next level is DOWN LEFT
DOWN RIGHT, next level is UP RIGHT
DOWN LEFT, next level is DOWN RIGHT
I don't mean upper left or downleft etc etc of map...Its the road leading to the top left/right etc.
Maphack For Path Of Diablo
General Observations
Another way to think of it is, in the hall or room you start out in, pretend you are in there yourself and looking towards the only direction that you can get out. now, simply follow the wall that is to the left of you
So always go to the left of which ever way the room or hall points to. More often then not it will be really close or diagonally across the map. This holds true with a lot of the 'underground' maps. Not always the case though. Heres some examples, the red arrow being the direction that the room points, green arrow being the left of the red arrow